La Macarena is a neighborhood of Seville, Spain, as well as a district, although the two are not entirely coterminous. The neighborhood is best known as being home to the Virgen de la Macarena (actually Nuestra Señora de la Esperanza de la Macarena), whose wooden statue dates from the 17th Century and can be found in the Basilica
Besides the Basilica de la Macarena, there are a number of other points of interest in this traditional Sevillan neighborhood. The largest surviving portion of the medieval city walls, built largely by the ruling Arabs prior to the city's reconquest in the 13th Century, spans from the Basilica (Puerta de la Macarena) to the Puerta de Cordoba, across the street from an old Monastery (Convento de los Capuchinos). This wall also divides the ancient zone of La Macarena from the modern zone, which forms part of the District by the same name.
The neighbourhood lends its name to the 1995 summer hit, "Macarena" by locals Los del Rio.